HISTO-AMELIORATIVE EFFECT OF PLEUROTUS TUBERREGIUM AGAINST LEAD INDUCED HEART, SPLEEN AND LOWER GUT DAMAGE IN ALBINO RAT

This study evaluates ameliorative effect of Pleurotus tuberregium on the effects lead (Pb) using different concentrations /growers mash feed mixture in 90 Albino rats divided into six groups with three replicates (with 5 per group) for 21days pre-experimental stage proper acclimatization. There after all experimental were exposed to 0.1 g/l daily 21days. At end exposure period, salt was discontinued 21and 42days post-experimental stage. Tissues heart, spleen and lower gut then collected subsequently analyzed structural changes at every interval. The tissues stages showed normal as those control except which ileal mucosa chronic inflammatory cell infiltration muscularis propria. However, groups, observable damages heart transmural oedoma myocardial degeneration, interstitial haemorrhage coronary vascular hypertrophy), spleen(with focal activated follicles sinus hyperplasia.) (have atrophy propria) improved post 21 42 days increased content feed. results this demonstrated that P .tuberregium may ameliorate toxicity